Thursday, October 27, 2011

Accepting The Side Effects

I'm cranky right now.  Oh, yes its the PIO shot causing the mood.  But its not just because of the injection its because I finally read through the list of side effects.  No, not the side effect to me but to the unborn child.

What I want to know is why didn't my doctor tell me that the baby could be harmed?

The following information is copied directly from the information booklet of my Progesterone box.

     The use of progestational drugs during the first four months of pregnancy is not recommended.  Progestational agents have been used beginning with the first trimester of pregnancy in attempts to prevent abortion but there is no evidence that such use is effective.  Furthermore, the use of progestational agents, with their uterine-relaxant properties, in patients with fertilized defective ova may cause a delay in spontaneous abortion
     Several reports suggest an association between intrauterine exposure to progestational drugs in the first trimester of pregnancy and genital abnormalities in male and female fetuses.  (it goes on here to describe the abnormalities and lets just say that I wouldn't wish it up on my kid)  There are insufficient data to quantify the risk to exposed female fetuses, but insofar as some of these- drugs induce mild virilzation of the external genitalia of the female fetus, and because of the increased association of the hypospadia in the male fetus, it is prudent to avoid the use of these drugs during the first trimester of pregnancy

Then we get into the carcinogenic, and impairment of fertility part.
Long-term intramuscular administration of Medroxy-progesterone acetate (MPA) has been shown to produce mammary tumors in beagle dogs.  (should I be thankful I'm not a dog?)

Okay so the impairment of fertility isn't so bad since its temporary according to this and should stop when treatment is stopped.  Any one remember the depo shot?  A fellow blogger, Bleeding Tulip today just reported that it seems to be the cause of her infertility.  So I am a bit worried since it is basically the same stuff being an MPA.

I'm okay with it causing a rise in my already high blood pressure. I was warned that all my infertility treatments were going to do just that.  My cardiologist understood and opted to increase my dosage of my labetalol by doubling the amount I used to take.  I now take 200mg 2 times a day.

So I just have to be concerned with cancer in my boobs, and a few other things.  Like what you ask?  Let me tell you what else.

Cerebral thrombosis and embolism, neuro-ocular lesions, e.g. retinal thrombosis and optic neuritis.  Hey wait a minute I'm predispostioned to getting optic neuritis with my dad having it in both eyes.  I guess its a good thing that I already have Optic Disc Drusen, so does this mean I'll get both?  Probably not.

This is just a blog posting about me accepting all the side effects of the current medication to keep this baby in me.  I just hope that it doesn't screw the kid up and its born healthy.  I just hope that it is still in there attaching itself to my uterine lining.  Symptoms point to yes as the pain is now only located in the uterus and no longer in the ovaries.  Its only small twinges too.  I'm wondering though why they even prescribed it if they knew it could do this to a fetus.  Maybe its because I had the eggs retrieved and there is no corpus luteum to help keep the baby hostage errr...I mean keep it in my womb until its fully cooked.  Wait that doesn't sound much better either. 


  1. I used PIO injections with mine, and honestly the benefits outweighed the risks for me. Without progesterone supplementation I would have lost the pregnancy due to my hormonal imbalances. I think the risks with birth defects refers to taking high doses for an extended period of time (high levels of progesterone during a pregnancy can alter hormones in fetuses, but only very high doses for extended periods of time). Progesterone occurs naturally in pregnancy, in our cycles, and while some forms are more risky (like synthetic progesterone versus natural progesterone) but it always comes down to weighing the risks vs benefits.

  2. Wow, that's kind of creepy to think about... It's weird when drugs list the reason it is prescribed in the side effects section. Like "may cause depression and suicidal thoughts" on an anti-depressant. Or in this case, "may cause birth defects, abortion and infertility" on a drug prescribed so that you DON'T lose your pregnancy.

  3. Great. And I start my shots in four weeks. Wednesday, November 30th. So much to look forward to...

    Keeping my fingers crossed for good news in a few days. My phone is with me. Got that? :)


If you decide to be a Troll I will refuse to pay your toll and your comment will not appear.